Clinical Information on Sermorelin Forte
What is Sermorelin Forte?
Sermorelin Forte is an exciting new compounded medication that
harnesses the synergistic relationship of Sermorelin and Growth Hormone
Releasing Peptide-6 (GHRP6). It is now available by prescription.
Sermorelin is a synthetic Growth Hormone Releasing Hormone (GHRH) that mimics the body’s naturally produced GHRH from the
hypothalamus. Sermorelin by itself will stimulate the pituitary gland in the base of the brain to release Growth Hormone (GH).6
GHRP6 is a synthetic peptide that directly stimulates the pituitary gland to produce more GH. Additionally, GHRP6 stimulates the
hypothalamus to release naturally produced GHRH.10,11,13,20,21,23 When using Sermorelin and GHRP6 together, Sermorelin Forte,
stimulation of both the production and release of more endogenous GH will occur, aiding in increasing the body’s natural GH levels.
Benefits of Sermorelin Forte
- By increasing the levels of growth hormone10,11,13,20,21,23, it is reported to assist in1:
Increased calcium retention
Stronger bone density
Increased muscle mass through sarcomere hyperplasia (additional division of the contractile unit of a muscle)
Increases protein synthesis
Stimulates the growth of all internal organs excluding the brain
Promotion of lipolysis (the process where fat cell are broken down)
Plays a role in energy homeostasis
Reduces liver uptake of glucose, promoting gluconeogenesis (formation of glucose from non-carbohydrate
source, i.e. energy formation from fat breakdown)
Contributes to the maintenance and function of pancreatic islets
Stimulates the immune system
- Increase stature in children with diagnosed short stature
- Treatment of the prevention of HIV-induced cachexia
- Possible blockage of oxidized-LDL binding, resulting in lower atherosclerotic plaque production10,23
This will reduce the risk for developing:
Myocardial Infarction – “Heart Attack”
- Promotes the breakdown of body fat while promoting lean muscle mass
Sermorelin Forte’s Clinical Pearls
Although GH has these favorable effects, too much GH can increase the thickness of the bones of the jaw, fingers and toes can
cause muscle weakness, insulin resistance or even a rare form of type 2 diabetes, and reduced sexual function.4,29 Conversely, not
having enough GH is equally unfavorable because it can lead to short stature (in children), reduced muscle mass/strength, insulin
resistance, decreased concentration/loss of memory, and even reduced bone mass/strength.3 Due to the above, it is important to
have your IGF-1 and GH levels monitored throughout therapy.
Both of the medications in Sermorelin Forte have been found to have a very good safety profile. It is given as a subcutaneous
injection (just under the skin) via a small syringe once a day. Sermorelin Forte’s most commonly reported side effect was mild
injection site pain.10,11,13,15,20,21,23
Dosing Protocols for Sermorelin Forte
Currently available in two strengths and is dispensed in a vial as a reconstitutable medication for injection.
- · Sermorelin Forte 8.7 mg
For patients who are not on growth hormone therapies or patients switching from Sermorelin therapy alone
- · Sermorelin Forte 14.4 mg
Used for patients who DON’T respond adequately to Sermorelin therapy alone or are switching from GH therapy.